Ontology highlight
ABSTRACT:
SUBMITTER: Tan L
PROVIDER: S-EPMC6360088 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Tan Longzhi L Xing Dong D Xing Dong D Chang Chi-Han CH Li Heng H Xie X Sunney XS
Science (New York, N.Y.) 20180830 6405
Three-dimensional genome structures play a key role in gene regulation and cell functions. Characterization of genome structures necessitates single-cell measurements. This has been achieved for haploid cells but has remained a challenge for diploid cells. We developed a single-cell chromatin conformation capture method, termed Dip-C, that combines a transposon-based whole-genome amplification method to detect many chromatin contacts, called META (multiplex end-tagging amplification), and an alg ...[more]