Ontology highlight
ABSTRACT:
SUBMITTER: Adam SM
PROVIDER: S-EPMC6360144 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Adam Suzanne M SM Wijeratne Gayan B GB Rogler Patrick J PJ Diaz Daniel E DE Quist David A DA Liu Jeffrey J JJ Karlin Kenneth D KD
Chemical reviews 20181029 22
Heme-copper oxidases (HCOs) are terminal enzymes on the mitochondrial or bacterial respiratory electron transport chain, which utilize a unique heterobinuclear active site to catalyze the 4H<sup>+</sup>/4e<sup>-</sup> reduction of dioxygen to water. This process involves a proton-coupled electron transfer (PCET) from a tyrosine (phenolic) residue and additional redox events coupled to transmembrane proton pumping and ATP synthesis. Given that HCOs are large, complex, membrane-bound enzymes, bioi ...[more]