Ontology highlight
ABSTRACT:
SUBMITTER: Wang YY
PROVIDER: S-EPMC6360293 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Wang Ying-Ying YY Lyu Yan-Ning YN Xin Hong-Yi HY Cheng Jun-Ting JT Liu Xiao-Qin XQ Wang Xian-Wang XW Peng Xiao-Chun XC Xiang Ying Y Xin Victoria W VW Lu Cheng-Biao CB Ren Bo-Xu BX Liang Yan-Fang YF Ji Jia-Fu JF Ma Zhaowu Z Cui Shu-Zhong SZ Xin Hong-Wu HW
Journal of Cancer 20190101 2
An oncolytic herpes simplex virus (oHSV) has proven amenable in oncolytic virotherapy and was approved to treat melanoma. The immediate-early (IE) protein ICP27 encoded by gene UL54 is essential for HSV infection. Post-transcriptional modification of UL54 would increase tumor targeting of oHSVs. However, UL54 gene transcription regulatory sequences and factors were not reported yet. Here we isolated a new strain LXMW of type 1 HSV (HSV-1-LXMW) in China and found it's closely related to HSV-1 str ...[more]