Ontology highlight
ABSTRACT:
SUBMITTER: Fidai SS
PROVIDER: S-EPMC6360833 | biostudies-literature | 2018 Oct-Dec
REPOSITORIES: biostudies-literature
Fidai Shiraz S SS Sharma Aarti E AE Johnson Daniel N DN Segal Jeremy P JP Lastra Ricardo R RR
Autopsy & case reports 20181001 4
5-Fluorouracil (5-FU), in combination with other cytotoxic drugs, is commonly used to treat a variety of cancers. Dihydropyrimidine dehydrogenase (DPD) catalyzes the first catabolic step of the 5-FU degradation pathway, converting 80% of 5-FU to its inactive metabolite. Approximately 0.3% of the population demonstrate complete DPD deficiency, translating to extreme toxicity of 5-FU. Here we present a case of a patient who had a fatal outcome after treatment with 5-FU who was found to have an unk ...[more]