Dataset Information

Long-term prognosis of Japanese patients with biologic-naive Crohn's disease treated with anti-tumor necrosis factor-? antibodies.

ABSTRACT:

Background/aims

Few reports have described the long-term treatment outcomes of the anti-tumor necrosis factor-? antibody for Japanese Crohn's disease (CD) patients. The aim of this study was to evaluate them and clarify the clinical factors that affect the long-term prognosis of the anti-tumor necrosis factor-? treatments.

Methods

This was a retrospective, observational, single-center cohort study. Japanese CD patients treated with either infliximab or adalimumab as a first-line therapy were analyzed. The cumulative retention rates of the biologics, relapse-free survival, and surgery-free survival were analyzed using Kaplan-Meier methods. The clinical factors associated with the long-term outcomes were estimated by both the log-rank test and Cox proportional hazard model.

Results

The cumulative retention rate was significantly higher in the group with a concomitant elemental diet of ?900 kcal/day, baseline C-reactive protein (CRP) levels <2.6 mg/dL, and baseline serum albumin levels ?3.5 g/dL, respectively. The baseline serum albumin levels were also associated with both relapse-free and surgery-free survival. The lack of concomitant use of an elemental diet ?900 kcal/day was identified as the only independent risk factor for the withdrawal of the biologics.

Conclusions

Baseline CRP levels and serum albumin levels could affect the long-term outcomes in CD patients. Concomitant elemental diet of ?900 kcal/day could have a positive influence on clinical treatment course.

SUBMITTER: Moroi R

PROVIDER: S-EPMC6361023 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Publications

Long-term prognosis of Japanese patients with biologic-naïve Crohn's disease treated with anti-tumor necrosis factor-α antibodies.

Moroi Rintaro R Endo Katsuya K Yamamoto Katsutoshi K Naito Takeo T Onodera Motoyuki M Kuroha Masatake M Kanazawa Yoshitake Y Kimura Tomoya T Kakuta Yoichi Y Masamune Atsushi A Kinouchi Yoshitaka Y Shimosegawa Tooru T

Intestinal research 20181203 1

<h4>Background/aims</h4>Few reports have described the long-term treatment outcomes of the anti-tumor necrosis factor-α antibody for Japanese Crohn's disease (CD) patients. The aim of this study was to evaluate them and clarify the clinical factors that affect the long-term prognosis of the anti-tumor necrosis factor-α treatments.<h4>Methods</h4>This was a retrospective, observational, single-center cohort study. Japanese CD patients treated with either infliximab or adalimumab as a first-line t ...[more]

PMID: 30508475

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