Dataset Information

Alteration of Semantic Networks during Swear Words Processing in Schizophrenia.

ABSTRACT:

Objective

Positive symptoms, such as delusion and hallucination, commonly include negative emotional content in schizophrenia. We investigated the neural basis implicated during the processing of strong negative emotional words in patients with schizophrenia.

Methods

In our study, 35 patients with schizophrenia and 19 healthy controls were recruited, and the participants were asked to passively view the words that contained swearing and neutral content during functional magnetic resonance imaging.

Results

Patients with schizophrenia, compared to healthy controls, showed hypoactivation to the swear and neutral words stimuli in the left inferior frontal gyrus, left middle frontal gyrus, and left angular/supramarginal gyrus. More specifically, patients with remitted schizophrenia were found to have greater activation to the stimuli in the left middle/inferior frontal gyrus than patients with active schizophrenia. Furthermore, in the analysis of regions of interests, the left inferior and middle frontal gyrus activity was related to the severity of positive symptoms, including delusion and suspiciousness.

Conclusion

Our results suggest that patients with schizophrenia have difficulty in semantic processing and inhibitory control of swear words, and these abnormalities may be connected with the severity of positive symptoms.

SUBMITTER: Lee SW

PROVIDER: S-EPMC6361040 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Alteration of Semantic Networks during Swear Words Processing in Schizophrenia.

Lee Sang Won SW Jeong Bumseok B Park Jong-Il JI Chung Gyung Ho GH Lee Hyo-Jong HJ Cui Yin Y Kim Woo-Sung WS Oh Kang Han KH Oh Il Seok IS Shen Guang Fan GF Chung Young-Chul YC

Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology 20190201 1

<h4>Objective</h4>Positive symptoms, such as delusion and hallucination, commonly include negative emotional content in schizophrenia. We investigated the neural basis implicated during the processing of strong negative emotional words in patients with schizophrenia.<h4>Methods</h4>In our study, 35 patients with schizophrenia and 19 healthy controls were recruited, and the participants were asked to passively view the words that contained swearing and neutral content during functional magnetic r ...[more]

PMID: 30690941

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Dataset Information

Alteration of Semantic Networks during Swear Words Processing in Schizophrenia.

Objective

Methods

Results

Conclusion

Publications

Alteration of Semantic Networks during Swear Words Processing in Schizophrenia.

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