Ontology highlight
ABSTRACT:
SUBMITTER: Sahasrabudhe NM
PROVIDER: S-EPMC6361794 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Sahasrabudhe Neha M NM van der Horst Joost C JC Spaans Vivian V Kenter Gemma G de Kroon Cor C Bosse Tjalling T van Vliet Sandra J SJ Jordanova Ekaterina S ES
Frontiers in oncology 20190129
Cervical cancer is the fourth most common cancer type in women worldwide and is characterized by a highly immune-suppressive microenvironment. Here, we describe aberrant glycosylation as a factor mediating this immunosuppressive microenvironment. Expression of a specific carbohydrate ligand for the immune-regulatory C-type lectin MGL was correlated to poor disease-specific survival and distant recurrences in squamous cell carcinoma (SCC) and adenosquamous carcinoma (ASC), the most common histolo ...[more]