Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland.
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ABSTRACT:
SUBMITTER: Arnau-Soler A
PROVIDER: S-EPMC6361928 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
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Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland.
Arnau-Soler Aleix A Macdonald-Dunlop Erin E Adams Mark J MJ Clarke Toni-Kim TK MacIntyre Donald J DJ Milburn Keith K Navrady Lauren L Hayward Caroline C McIntosh Andrew M AM Thomson Pippa A PA
Translational psychiatry 20190204 1
Stress is associated with poorer physical and mental health. To improve our understanding of this link, we performed genome-wide association studies (GWAS) of depressive symptoms and genome-wide by environment interaction studies (GWEIS) of depressive symptoms and stressful life events (SLE) in two UK population-based cohorts (Generation Scotland and UK Biobank). No SNP was individually significant in either GWAS, but gene-based tests identified six genes associated with depressive symptoms in U ...[more]
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