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Critical synchronization and 1/f noise in inhibitory/excitatory rich-club neural networks.

ABSTRACT: In recent years, diverse studies have reported that different brain regions, which are internally densely connected, are also highly connected to each other. This configuration seems to play a key role in integrating and interchanging information between brain areas. Also, changes in the rich-club connectivity and the shift from inhibitory to excitatory behavior of hub neurons have been associated with several diseases. However, there is not a clear understanding about the role of the proportion of inhibitory/excitatory hub neurons, the dynamic consequences of rich-club disconnection, and hub inhibitory/excitatory shifts. Here, we study the synchronization and temporal correlations in the neural Izhikevich model, which comprises excitatory and inhibitory neurons located in a scale-free hierarchical network with rich-club connectivity. We evaluated the temporal autocorrelations and global synchronization dynamics displayed by the system in terms of rich-club connectivity and hub inhibitory/excitatory population. We evaluated the synchrony between pairs of sets of neurons by means of the global lability synchronization, based on the rate of change in the total number of synchronized signals. The results show that for a wide range of excitatory/inhibitory hub ratios the network displays 1/f dynamics with critical synchronization that is concordant with numerous health brain registers, while a network configuration with a vast majority of excitatory hubs mostly exhibits short-term autocorrelations with numerous large avalanches. Furthermore, rich-club connectivity promotes the increase of the global lability of synchrony and the temporal persistence of the system.

SUBMITTER: Aguilar-Velazquez D

PROVIDER: S-EPMC6361933 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:The ability to simultaneously record from large numbers of neurons in behaving animals has ushered in a new era for the study of the neural circuit mechanisms underlying cognitive functions. One promising approach to uncovering the dynamical and computational principles governing population responses is to analyze model recurrent neural networks (RNNs) that have been optimized to perform the same tasks as behaving animals. Because the optimization of network parameters specifies the desired output but not the manner in which to achieve this output, "trained" networks serve as a source of mechanistic hypotheses and a testing ground for data analyses that link neural computation to behavior. Complete access to the activity and connectivity of the circuit, and the ability to manipulate them arbitrarily, make trained networks a convenient proxy for biological circuits and a valuable platform for theoretical investigation. However, existing RNNs lack basic biological features such as the distinction between excitatory and inhibitory units (Dale's principle), which are essential if RNNs are to provide insights into the operation of biological circuits. Moreover, trained networks can achieve the same behavioral performance but differ substantially in their structure and dynamics, highlighting the need for a simple and flexible framework for the exploratory training of RNNs. Here, we describe a framework for gradient descent-based training of excitatory-inhibitory RNNs that can incorporate a variety of biological knowledge. We provide an implementation based on the machine learning library Theano, whose automatic differentiation capabilities facilitate modifications and extensions. We validate this framework by applying it to well-known experimental paradigms such as perceptual decision-making, context-dependent integration, multisensory integration, parametric working memory, and motor sequence generation. Our results demonstrate the wide range of neural activity patterns and behavior that can be modeled, and suggest a unified setting in which diverse cognitive computations and mechanisms can be studied.

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Critical synchronization and 1/f noise in inhibitory/excitatory rich-club neural networks.

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