Dynamic expression of genes associated with schizophrenia and bipolar disorder across development.

ABSTRACT: Common genetic variation contributes a substantial proportion of risk for both schizophrenia and bipolar disorder. Furthermore, there is evidence of significant, but not complete, overlap in genetic risk between the two disorders. It has been hypothesised that genetic variants conferring risk for these disorders do so by influencing brain development, leading to the later emergence of symptoms. The comparative profile of risk gene expression for schizophrenia and bipolar disorder across development over different brain regions however remains unclear. Using genotypes derived from genome-wide associations studies of the largest available cohorts of patients and control subjects, we investigated whether genes enriched for schizophrenia and bipolar disorder association show a bias for express

SUBMITTER: Clifton NE 

PROVIDER: S-EPMC6362023 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature