Genetic loci for alcohol-related life events and substance-induced affective symptoms: indexing the "dark side" of addiction.

ABSTRACT: A limited number of genetic variants have been identified in traditional GWAS as risk or protective factors for alcohol use disorders (AUD) and related phenotypes. We herein report whole-genome association and rare-variant analyses on AUD traits in American Indians (AI) and European Americans (EA). We evaluated 742 AIs and 1711 EAs using low-coverage whole-genome sequencing. Phenotypes included: (1) a metric based on the occurrence of 36 alcohol-related life events that reflect AUD severity; (2) two alcohol-induced affective symptoms that accompany severe AUDs. We identified two new loci for alcohol-related life events with converging evidence from both cohorts: rare variants of K_2P channel gene KCNK2, and rare missense and splice-site variants in pro-inflammatory mediator gene

SUBMITTER: Peng Q 

PROVIDER: S-EPMC6362044 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature