Ontology highlight
ABSTRACT:
SUBMITTER: Rosato PC
PROVIDER: S-EPMC6362136 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Rosato Pamela C PC Wijeyesinghe Sathi S Stolley J Michael JM Nelson Christine E CE Davis Rachel L RL Manlove Luke S LS Pennell Christopher A CA Blazar Bruce R BR Chen Clark C CC Geller Melissa A MA Vezys Vaiva V Masopust David D
Nature communications 20190204 1
The immunosuppressive tumor microenvironment limits the success of current immunotherapies. The host retains memory T cells specific for previous infections throughout the entire body that are capable of executing potent and immediate immunostimulatory functions. Here we show that virus-specific memory T cells extend their surveillance to mouse and human tumors. Reactivating these antiviral T cells can arrest growth of checkpoint blockade-resistant and poorly immunogenic tumors in mice after inj ...[more]