Dataset Information

Tracking perceptual decision mechanisms through changes in interhemispheric functional connectivity in human visual cortex.

ABSTRACT: The role of long-range integration mechanisms underlying visual perceptual binding and their link to interhemispheric functional connectivity, as measured by fMRI, remains elusive. Only inferences on anatomical organization from resting state data paradigms not requiring coherent binding have been achieved. Here, we used a paradigm that allowed us to study such relation between perceptual interpretation and functional connectivity under bistable interhemispheric binding vs. non-binding of visual surfaces. Binding occurs by long-range perceptual integration of motion into a single object across hemifields and non-binding reflects opponent segregation of distinct moving surfaces into each hemifield. We hypothesized that perceptual integration vs. segregation of surface motion, which is achieved in visual area hMT+, is modulated by changes in interhemispheric connectivity in this region. Using 7T fMRI, we found that perceptual long-range integration of bistable motion can be tracked by changes in interhemispheric functional connectivity between left/right hMT+. Increased connectivity was tightly related with long-range perceptual integration. Our results indicate that hMT+ interhemispheric functional connectivity reflects perceptual decision, suggesting its pivotal role on long-range disambiguation of bistable physically constant surface motion. We reveal for the first time, at the scale of fMRI, a relation between interhemispheric functional connectivity and decision based perceptual binding.

SUBMITTER: Sousa T

PROVIDER: S-EPMC6362201 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Tracking perceptual decision mechanisms through changes in interhemispheric functional connectivity in human visual cortex.

Sousa Teresa T Duarte João V JV Costa Gabriel N GN Kemper Valentin G VG Martins Ricardo R Goebel Rainer R Castelo-Branco Miguel M

Scientific reports 20190204 1

The role of long-range integration mechanisms underlying visual perceptual binding and their link to interhemispheric functional connectivity, as measured by fMRI, remains elusive. Only inferences on anatomical organization from resting state data paradigms not requiring coherent binding have been achieved. Here, we used a paradigm that allowed us to study such relation between perceptual interpretation and functional connectivity under bistable interhemispheric binding vs. non-binding of visual ...[more]

PMID: 30718636

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Project description:Introduction: Repetitive transcranial magnetic stimulation (rTMS) is a promising therapeutic technique, and is believed to accomplish its effect by influencing the stimulated and remotely connected areas. However, responsiveness to rTMS shows high interindividual variability, and this intersubject variability is particularly high in older adults. It remains unclear whether baseline resting-state functional connectivity (rsFC) contributes to this variability in older adults. The aims of this study are to (1) examine rTMS effects over the primary motor cortex (M1) in older adults, and (2) identify baseline network properties that may contribute to the interindividual variability. Methods: We tested response to intermittent theta burst stimulation (iTBS), an effective rTMS protocol, over M1 by using both electromyography and resting-state functional magnetic resonance imaging in older adults. Outcome measures included motor-evoked potential (MEP) elicited by single-pulse transcranial magnetic stimulation and rsFC before and after an iTBS session. Results: iTBS significantly increased MEP amplitudes and rsFC between the stimulation site, sensorimotor cortex, and supplementary motor area (SMA) in older adults. iTBS-induced changes in MEP amplitude were positively correlated with increases in interhemispheric rsFC after iTBS. Furthermore, older adults with lower baseline interhemispheric rsFC between sensorimotor cortex and SMA exhibited stronger MEP response after iTBS. Discussion: Findings of the study suggest that different levels of interhemispheric communication during resting state might contribute to the response heterogeneity to iTBS in older adults. Interhemispheric rsFC may have great potential serving as a useful marker for predicting iTBS responsiveness in older adults. ClinicalTrials.gov ID: 1707654427 Impact statement Factors contributing to interindividual variability of the responsive to repetitive transcranial magnetic stimulation (rTMS) in older adults remain poorly understood. In this study, we examined the effects of rTMS over the primary motor cortex in older adults, and found that response to rTMS is associated with prestimulation interhemispheric connectivity in the sensorimotor and premotor areas. Findings of the study have great potential to be translated into a connectivity-based strategy for identification of responders for rTMS in older adults.

Dataset Information

Tracking perceptual decision mechanisms through changes in interhemispheric functional connectivity in human visual cortex.

Publications

Tracking perceptual decision mechanisms through changes in interhemispheric functional connectivity in human visual cortex.

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