Ontology highlight
ABSTRACT:
SUBMITTER: Leger C
PROVIDER: S-EPMC6362204 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Léger Corentin C Di Meo Thibault T Aumont-Nicaise Magali M Velours Christophe C Durand Dominique D Li de la Sierra-Gallay Ines I van Tilbeurgh Herman H Hildebrandt Niko N Desmadril Michel M Urvoas Agathe A Valerio-Lepiniec Marie M Minard Philippe P
Scientific reports 20190204 1
Artificial proteins binding any predefined "target" protein can now be efficiently generated using combinatorial libraries based on robust protein scaffolds. αRep is such a family of artificial proteins, based on an α-solenoid protein repeat scaffold. The low aggregation propensity of the specific "binders" generated from this library opens new protein engineering opportunities such as the creation of biosensors within multidomain constructions. Here, we have explored the properties of two new t ...[more]