Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC6362815 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Zhang Honghong H Brown Rhonda L RL Wei Yong Y Zhao Pu P Liu Sali S Liu Xuan X Deng Yu Y Hu Xiaohui X Zhang Jing J Gao Xin D XD Kang Yibin Y Mercurio Arthur M AM Goel Hira Lal HL Cheng Chonghui C
Genes & development 20190128 3-4
Although changes in alternative splicing have been observed in cancer, their functional contributions still remain largely unclear. Here we report that splice isoforms of the cancer stem cell (CSC) marker CD44 exhibit strikingly opposite functions in breast cancer. Bioinformatic annotation in patient breast cancer in The Cancer Genome Atlas (TCGA) database reveals that the CD44 standard splice isoform (CD44s) positively associates with the CSC gene signatures, whereas the CD44 variant splice iso ...[more]