Ontology highlight
ABSTRACT:
SUBMITTER: Anikeeva N
PROVIDER: S-EPMC6362847 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Anikeeva Nadia N Fischer Nicholas O NO Blanchette Craig D CD Sykulev Yuri Y
Journal of immunology (Baltimore, Md. : 1950) 20181212 2
MHC proteins that present peptide ligands for recognition by TCR form nanoscale clusters on the cell membrane of APCs. How the extent of MHC clustering controls productive TCR engagement and TCR-mediated signaling has not been systematically studied. To evaluate the role of MHC clustering, we exploited nanoscale discoidal membrane mimetics (nanolipoprotein particles) to capture and present peptide-MHC (pMHC) ligands at various densities. We examined the binding of these model membrane clusters t ...[more]