Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC6363135 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Yang Jiaying J Li Jingxin J Wang Shiyuan S Luo Li L Liu Pei P
Human vaccines & immunotherapeutics 20181004 1
Clinical trials that study immunogenicity of combination vaccines often have less power than desirable. To make up for the reduction in statistical power at the study level, researchers have to increase the study sample size. To study immunogenicity variables, we used the geometric mean concentration of immune response after vaccination as immunologic endpoint and compared 3 sample size calculation methods: the "Inflation factors" method, the "Incrementing" method, and the "Bonferroni correction ...[more]