Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez-Sanchez I
PROVIDER: S-EPMC6363234 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Rodríguez-Sánchez Irene I Schafer Xenia L XL Monaghan Morgan M Munger Joshua J
PLoS pathogens 20190124 1
Human Cytomegalovirus (HCMV) infection induces several metabolic activities that are essential for viral replication. Despite the important role that this metabolic modulation plays during infection, the viral mechanisms involved are largely unclear. We find that the HCMV UL38 protein is responsible for many aspects of HCMV-mediated metabolic activation, with UL38 being necessary and sufficient to drive glycolytic activation and induce the catabolism of specific amino acids. UL38's metabolic rep ...[more]