Ontology highlight
ABSTRACT:
SUBMITTER: Cui Y
PROVIDER: S-EPMC6363445 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Cui Yi Y Carosi Julian M JM Yang Zhe Z Ariotti Nicholas N Kerr Markus C MC Parton Robert G RG Sargeant Timothy J TJ Teasdale Rohan D RD
The Journal of cell biology 20181217 2
Retromer is a peripheral membrane protein complex that coordinates multiple vesicular trafficking events within the endolysosomal system. Here, we demonstrate that retromer is required for the maintenance of normal lysosomal morphology and function. The knockout of retromer subunit Vps35 causes an ultrastructural alteration in lysosomal structure and aberrant lysosome function, leading to impaired autophagy. At the whole-cell level, knockout of retromer Vps35 subunit reduces lysosomal proteolyti ...[more]