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Triallelic relationships between the serotonin transporter polymorphism and cognition among healthy older adults.


ABSTRACT: The biallelic serotonin transporter polymorphism (5-hydroxytryptamine transporter linked polymorphic region (5-HTTLPR)) is a common genetic sequence associated with serotonin transporter (5-hydroxytryptamine transporter (5-HTT)) expression, which is further modulated by a triallelic single-nucleotide polymorphism (rs25531). Recent studies using the biallelic 5-HTTLPR have identified a beneficial role of low 5-HTT expression on cognitive performance, although no studies have examined the impact of the triallelic 5-HTTLPR/rs25531 marker on cognitive performance among healthy older adults. In the present study, we addressed this issue in 84 healthy older adults genotyped for biallelic and triallelic variants of 5-HTT. Groups were created based on low, medium and high levels of expression, as indicated by the triallelic marker. Results indicated that individuals with low 5-HTT expression performed significantly better on a test of memory compared with individuals with medium 5-HTT expression. This suggests that possession of low-expressing genetic variants of 5-HTT is modestly associated with enhanced cognitive performance among healthy older adults.

SUBMITTER: Salminen LE 

PROVIDER: S-EPMC6363532 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Triallelic relationships between the serotonin transporter polymorphism and cognition among healthy older adults.

Salminen Lauren E LE   Schofield Peter R PR   Pierce Kerrie D KD   Lane Elizabeth M EM   Heaps Jodi M JM   Bolzenius Jacob D JD   Baker Laurie M LM   Luo Xi X   Paul Robert H RH  

The International journal of neuroscience 20131017 5


The biallelic serotonin transporter polymorphism (5-hydroxytryptamine transporter linked polymorphic region (5-HTTLPR)) is a common genetic sequence associated with serotonin transporter (5-hydroxytryptamine transporter (5-HTT)) expression, which is further modulated by a triallelic single-nucleotide polymorphism (rs25531). Recent studies using the biallelic 5-HTTLPR have identified a beneficial role of low 5-HTT expression on cognitive performance, although no studies have examined the impact o  ...[more]

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