NrtR Regulates the Type III Secretion System Through cAMP/Vfr Pathway in Pseudomonas aeruginosa.
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ABSTRACT:
SUBMITTER: Jin Y
PROVIDER: S-EPMC6363681 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
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NrtR Regulates the Type III Secretion System Through cAMP/Vfr Pathway in <i>Pseudomonas aeruginosa</i>.
Jin Yongxin Y Zhang Mengjing M Zhu Feng F Peng Qianqian Q Weng Yuding Y Zhao Qiang Q Liu Chang C Bai Fang F Cheng Zhihui Z Jin Shouguang S Wu Weihui W
Frontiers in microbiology 20190130
The type III secretion system (T3SS) plays an important role in the pathogenesis of <i>Pseudomonas aeruginosa</i>. Expression of the T3SS is controlled under a complicate regulatory network. In this study, we demonstrate that NrtR (PA4916) is involved in the T3SS expression and pathogenesis of <i>P. aeruginosa</i> in a mouse acute pneumonia model. Overexpression of the T3SS central activator ExsA or exogenous supplementation of cAMP restored the expression of T3SS in the Δ<i>nrtR</i> mutant, sug ...[more]
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