Ontology highlight
ABSTRACT:
SUBMITTER: Landuyt AE
PROVIDER: S-EPMC6363853 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20190114 4
The ICOS pathway has been implicated in the development and functions of regulatory T (Treg) cells, including those producing IL-10. Treg cell-derived IL-10 is indispensable for the establishment and maintenance of intestinal immune homeostasis. We examined the possible involvement of the ICOS pathway in the accumulation of murine colonic Foxp3- and/or IL-10-expressing cells. We show that ICOS deficiency does not impair induction of IL-10 by intestinal CD4 T cells but, instead, triggers substant ...[more]