Ontology highlight
ABSTRACT:
SUBMITTER: Ashton NJ
PROVIDER: S-EPMC6365111 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Science advances 20190206 2
A blood-based assessment of preclinical disease would have huge potential in the enrichment of participants for Alzheimer's disease (AD) therapeutic trials. In this study, cognitively unimpaired individuals from the AIBL and KARVIAH cohorts were defined as Aβ negative or Aβ positive by positron emission tomography. Nontargeted proteomic analysis that incorporated peptide fractionation and high-resolution mass spectrometry quantified relative protein abundances in plasma samples from all particip ...[more]