Ontology highlight
ABSTRACT:
SUBMITTER: Hou L
PROVIDER: S-EPMC6365112 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Science advances 20190206 2
About 257 million people with chronic infection of hepatitis B virus (HBV) worldwide are at high risk of developing terminal liver diseases. Reactivation of virus replication has been frequently reported in those patient populations receiving imatinib (an Abl kinase inhibitor) or bortezomib (a proteasome inhibitor) to treat concurrent diseases, but the underlying mechanism for this reactivation is unknown. We report that the HBV polymerase protein is recruited by Cdt2 to the cullin-RING ligase 4 ...[more]