Ontology highlight
ABSTRACT:
SUBMITTER: Peng Y
PROVIDER: S-EPMC6365180 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Peng Yi Y Cao Shufen S Kiselar Janna J Xiao Xiangzhu X Du Zhanwen Z Hsieh An A Ko Soobin S Chen Yinghua Y Agrawal Prashansa P Zheng Wenwei W Shi Wuxian W Jiang Wei W Yang Lin L Chance Mark R MR Surewicz Witold K WK Buck Matthias M Yang Sichun S
Structure (London, England : 1993) 20181220 2
The N-terminal transactivation domain (NTD) of estrogen receptor alpha, a well-known member of the family of intrinsically disordered proteins, mediates the receptor's transactivation function. However, an accurate molecular dissection of NTD's structure-function relationships remains elusive. Here, we show that the NTD adopts a mostly disordered, unexpectedly compact conformation that undergoes structural expansion on chemical denaturation. By combining small-angle X-ray scattering, hydroxyl ra ...[more]