Technical Feasibility of a Murine Model of Sleeve Gastrectomy with Ileal Transposition.

ABSTRACT:

Background

Sleeve gastrectomy with ileal transposition has been shown to be superior to sleeve gastrectomy alone for promoting weight loss in rat and porcine models. The absence of a mouse model for this procedure has impeded efforts to understand the molecular physiology underlying its efficacy. This study demonstrates the long-term survivability of sleeve gastrectomy with ileal transposition in mice.

Materials and methods

In this study of technical feasibility, a sleeve gastrectomy with ileal transposition (SGIT), sleeve gastrectomy (SG), or sham surgery (SH) was performed on 7- to 8-week-old C57Bl/6J mice (n = 8 for each). To evaluate long-term survivability, mice were placed on an obesogenic diet and weighed weekly for 10 weeks. The intestinal identity of the transposed

SUBMITTER: Ying LD 

PROVIDER: S-EPMC6365182 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature