Ontology highlight
ABSTRACT:
SUBMITTER: Shipman WD
PROVIDER: S-EPMC6365282 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Shipman William D WD Chyou Susan S Ramanathan Anusha A Izmirly Peter M PM Sharma Sneh S Pannellini Tania T Dasoveanu Dragos C DC Qing Xiaoping X Magro Cynthia M CM Granstein Richard D RD Lowes Michelle A MA Pamer Eric G EG Kaplan Daniel H DH Salmon Jane E JE Mehrara Babak J BJ Young James W JW Clancy Robert M RM Blobel Carl P CP Lu Theresa T TT
Science translational medicine 20180801 454
Photosensitivity, or skin sensitivity to ultraviolet radiation (UVR), is a feature of lupus erythematosus and other autoimmune and dermatologic conditions, but the mechanistic underpinnings are poorly understood. We identify a Langerhans cell (LC)-keratinocyte axis that limits UVR-induced keratinocyte apoptosis and skin injury via keratinocyte epidermal growth factor receptor (EGFR) stimulation. We show that the absence of LCs in Langerin-diphtheria toxin subunit A (DTA) mice leads to photosensi ...[more]