MiR-22 suppresses DNA ligase III addiction in multiple myeloma.
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ABSTRACT:
SUBMITTER: Caracciolo D
PROVIDER: S-EPMC6365379 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
miR-22 suppresses DNA ligase III addiction in multiple myeloma.
Caracciolo Daniele D Di Martino Maria Teresa MT Amodio Nicola N Morelli Eugenio E Montesano Martina M Botta Cirino C Scionti Francesca F Talarico Daniela D Altomare Emanuela E Gallo Cantafio Maria Eugenia ME Zuccalà Valeria V Maltese Lorenza L Todoerti Katia K Rossi Marco M Arbitrio Mariamena M Neri Antonino A Tagliaferri Pierosandro P Tassone Pierfrancesco P
Leukemia 20180817 2
Multiple myeloma (MM) is a hematologic malignancy characterized by high genomic instability. Here we provide evidence that hyper-activation of DNA ligase III (LIG3) is crucial for genomic instability and survival of MM cells. LIG3 mRNA expression in MM patients correlates with shorter survival and even increases with more advanced stage of disease. Knockdown of LIG3 impairs MM cells viability in vitro and in vivo, suggesting that neoplastic plasmacells are dependent on LIG3-driven repair. To inv ...[more]
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