Humanized Mouse Model Mimicking Pathology of Human Tuberculosis for in vivo Evaluation of Drug Regimens.
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ABSTRACT:
SUBMITTER: Arrey F
PROVIDER: S-EPMC6365439 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Humanized Mouse Model Mimicking Pathology of Human Tuberculosis for <i>in vivo</i> Evaluation of Drug Regimens.
Arrey Frida F Löwe Delia D Kuhlmann Stefanie S Kaiser Peggy P Moura-Alves Pedro P Krishnamoorthy Gopinath G Lozza Laura L Maertzdorf Jeroen J Skrahina Tatsiana T Skrahina Alena A Gengenbacher Martin M Nouailles Geraldine G Kaufmann Stefan H E SHE
Frontiers in immunology 20190131
Human immune system mice are highly valuable for <i>in vivo</i> dissection of human immune responses. Although they were employed for analyzing tuberculosis (TB) disease, there is little data on the spatial organization and cellular composition of human immune cells in TB granuloma pathology in this model. We demonstrate that human immune system mice, generated by transplanted human fetal liver derived hematopoietic stem cells develop a continuum of pulmonary lesions upon <i>Mycobacterium tuberc ...[more]
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