Recurrent activating STAT5B N642H mutation in myeloid neoplasms with eosinophilia.

ABSTRACT: Determining the underlying cause of persistent eosinophilia is important for effective clinical management but remains a diagnostic challenge in many cases. We identified STAT5B N642H, an established oncogenic mutation, in 27/1715 (1.6%) cases referred for investigation of eosinophilia. Of the 27 mutated cases, a working diagnosis of hypereosinophilic syndrome (HES; n?=?7) or a myeloid neoplasm with eosinophilia (n?=?20) had been made prior to the detection of STAT5B N642H. Myeloid panel analysis identified a median of 2 additional mutated genes (range 0-4) with 4 cases having STAT5B N642H as a sole abnormality. STAT5B N642H was absent in cultured T cells of 4/4 positive cases. Individuals with SF3B1 mutations (9/27; 33%) or STAT5B N642H as a sole abnormality had a markedly better overall survival compared to cases with other additional mutations (median 65 months vs. 14 months; hazard ratio?=?8.1; P?

SUBMITTER: Cross NCP 

PROVIDER: S-EPMC6365490 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature