Ontology highlight
ABSTRACT:
SUBMITTER: Babu KR
PROVIDER: S-EPMC6365501 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Babu Kamesh R KR Muckenthaler Martina U MU
Scientific reports 20190206 1
Transferrin receptor 1 (TFR1) is a transmembrane glycoprotein that allows for transferrin-bound iron uptake in mammalian cells. It is overexpressed in various cancers to satisfy the high iron demand of fast proliferating cells. Here we show that in hepatocellular carcinoma (HCC) TFR1 expression is regulated by miR-148a. Within the TFR1 3'UTR we identified and experimentally validated two evolutionarily conserved miRNA response elements (MREs) for miR-148/152 family members, including miR-148a. I ...[more]