Ontology highlight
ABSTRACT:
SUBMITTER: O'Doherty AM
PROVIDER: S-EPMC6365515 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
O'Doherty Alan Mark AM Rue-Albrecht Kevin Christophe KC Magee David Andrew DA Ahting Simone S Irwin Rachelle Elizabeth RE Hall Thomas Jonathan TJ Browne John Arthur JA Nalpas Nicolas Claude NC Walsh Colum Patrick CP Gordon Stephen Vincent SV Wojewodzic Marcin Włodzimierz MW MacHugh David Evan DE
Scientific reports 20190206 1
DNA methylation is pivotal in orchestrating gene expression patterns in various mammalian biological processes. Perturbation of the bovine alveolar macrophage (bAM) transcriptome, due to Mycobacterium bovis (M. bovis) infection, has been well documented; however, the impact of this intracellular pathogen on the bAM epigenome has not been determined. Here, whole genome bisulfite sequencing (WGBS) was used to assess the effect of M. bovis infection on the bAM DNA methylome. The methylomes of bAM i ...[more]