Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC6365567 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Li Xuanan X Islam Shamima S Xiong Min M Nsumu Ndona N NN Lee Mark W MW Zhang Li Qin LQ Ueki Yasuyoshi Y Heruth Daniel P DP Lei Guanghua G Ye Shui Qing SQ
Cell death discovery 20190206
Nicotinamide phosphoribosyltransferase (NAMPT) functions in NAD synthesis, apoptosis, and inflammation. Dysregulation of NAMPT has been associated with several inflammatory diseases, including rheumatoid arthritis (RA). The purpose of this study was to investigate NAMPT's role in arthritis using mouse and cellular models. Collagen-induced arthritis (CIA) in DBA/1J <i>Nampt</i> <sup>+/-</sup> mice was evaluated by ELISA, micro-CT, and RNA-sequencing (RNA-seq). In vitro Nampt loss-of-function and ...[more]