Ontology highlight
ABSTRACT:
SUBMITTER: Crowe LAN
PROVIDER: S-EPMC6365574 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Crowe Lindsay A N LAN McLean Michael M Kitson Susan M SM Melchor Emma Garcia EG Patommel Katharina K Cao Hai Man HM Reilly James H JH Leach William J WJ Rooney Brain P BP Spencer Simon J SJ Mullen Michael M Chambers Max M Murrell George A C GAC McInnes Iain B IB Akbar Moeed M Millar Neal L NL
Scientific reports 20190206 1
Alarmins S100A8 and S100A9 are endogenous molecules released in response to environmental triggers and cellular damage. They are constitutively expressed in immune cells such as monocytes and neutrophils and their expression is upregulated under inflammatory conditions. The molecular mechanisms that regulate inflammatory pathways in tendinopathy are largely unknown therefore identifying early immune effectors is essential to understanding the pathology. Based on our previous investigations highl ...[more]