Dataset Information

Acute reperfusion without recanalization: Serial assessment of collaterals within 6?h of using perfusion-weighted magnetic resonance imaging.

ABSTRACT: Acute reperfusion despite persistent arterial occlusion may occur in up to 30% of ischemic stroke patients. Recruitment of leptomeningeal collaterals may explain this phenomenon. Using dynamic susceptibility-contrast perfusion imaging (DSC-PI), we assessed acute changes in collateral flow among patients without recanalization. From a multicenter prospective database (I-KNOW), 46 patients with magnetic resonance angiography visible occlusion in whom both reperfusion and recanalization were assessed within 6?h of onset were identified. Maps of collateral flow at arterial, capillary and late venous phases were generated from DSC-PI through inter-frame registration, baseline signal subtraction and temporal summation, and graded blind to all other relevant clinical and radiological data using the Higashida scale. Flow direction and the acute evolution of collaterals were evaluated against the reperfusion status. Among patients without recanalization ( n?=?33), flow direction remained retrograde. Collateral grades significantly improved between admission and acute follow-up in patients who reperfused (OR: 4.57; 95% CI: 1.1-22.7; p?=?0.048), but not in those without reperfusion (OR: 1.34; 95% CI: 0.4-4.5; p?=?0.623). Our study confirmed that acute reperfusion without recanalization is associated with a significant improvement of retrograde collateral flow. DSC-PI can detect acute changes in collateral flow, and may help evaluate novel treatments targeting leptomeningeal collaterals.

SUBMITTER: Makris N

PROVIDER: S-EPMC6365601 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Acute reperfusion without recanalization: Serial assessment of collaterals within 6 h of using perfusion-weighted magnetic resonance imaging.

Makris Nikolaos N Chamard Leila L Mikkelsen Irene K IK Hermier Marc M Derex Laurent L Pedraza Salvador S Thomalla Götz G Østergaard Leif L Baron Jean-Claude JC Nighoghossian Norbert N Berthezène Yves Y Cho Tae-Hee TH

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20180102 2

Acute reperfusion despite persistent arterial occlusion may occur in up to 30% of ischemic stroke patients. Recruitment of leptomeningeal collaterals may explain this phenomenon. Using dynamic susceptibility-contrast perfusion imaging (DSC-PI), we assessed acute changes in collateral flow among patients without recanalization. From a multicenter prospective database (I-KNOW), 46 patients with magnetic resonance angiography visible occlusion in whom both reperfusion and recanalization were assess ...[more]

PMID: 29291673

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Dataset Information

Acute reperfusion without recanalization: Serial assessment of collaterals within 6?h of using perfusion-weighted magnetic resonance imaging.

Publications

Acute reperfusion without recanalization: Serial assessment of collaterals within 6 h of using perfusion-weighted magnetic resonance imaging.

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