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Chlortetracycline Enhances Tonsil Colonization and Fecal Shedding of Multidrug-Resistant Salmonella enterica Serovar Typhimurium DT104 without Major Alterations to the Porcine Tonsillar and Intestinal Microbiota.


ABSTRACT: Salmonella spp. are estimated to cause 1.2 million cases of human foodborne illness each year in the United States, and pigs can often be asymptomatically colonized with Salmonella spp. (>50% of farms). Recent reports state that 18.3% of Salmonella enterica serovar Typhimurium isolates are resistant to ?3 antimicrobial classes, and multidrug-resistant (MDR) strains are associated with an increased hospitalization rate and other complications. Chlortetracycline is commonly used in swine production to prevent/treat various diseases; therefore, chlortetracycline treatment of pigs unknowingly colonized with MDR Salmonella may have collateral effects on Salmonella spp. (and other gut bacteria). In this study, we determined the effect of in-feed chlortetracycline (400?g/ton) on shedding and colonization of pigs challenged with the MDR S Typhimurium strain DT104 (n = 11/group). We also assessed the impact on the fecal microbiota over the 12-day experimental period and on the ileum, cecum, and tonsil microbiota at 7?days postinoculation (dpi). In MDR S Typhimurium-inoculated pigs, chlortetracycline administration significantly increased fecal shedding at 2?dpi (+1.4 log10 CFU/g; P?

SUBMITTER: Holman DB 

PROVIDER: S-EPMC6365817 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Chlortetracycline Enhances Tonsil Colonization and Fecal Shedding of Multidrug-Resistant <i>Salmonella enterica</i> Serovar Typhimurium DT104 without Major Alterations to the Porcine Tonsillar and Intestinal Microbiota.

Holman Devin B DB   Bearson Bradley L BL   Allen Heather K HK   Shippy Daniel C DC   Loving Crystal L CL   Kerr Brian J BJ   Bearson Shawn M D SMD   Brunelle Brian W BW  

Applied and environmental microbiology 20190206 4


<i>Salmonella</i> spp. are estimated to cause 1.2 million cases of human foodborne illness each year in the United States, and pigs can often be asymptomatically colonized with <i>Salmonella</i> spp. (>50% of farms). Recent reports state that 18.3% of <i>Salmonella enterica</i> serovar Typhimurium isolates are resistant to ≥3 antimicrobial classes, and multidrug-resistant (MDR) strains are associated with an increased hospitalization rate and other complications. Chlortetracycline is commonly us  ...[more]

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