Ontology highlight
ABSTRACT:
SUBMITTER: Secci D
PROVIDER: S-EPMC6366404 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Secci Daniela D Carradori Simone S Petzer Anél A Guglielmi Paolo P D'Ascenzio Melissa M Chimenti Paola P Bagetta Donatella D Alcaro Stefano S Zengin Gokhan G Petzer Jacobus P JP Ortuso Francesco F
Journal of enzyme inhibition and medicinal chemistry 20191201 1
A new series of 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives were designed, synthesised, and evaluated to assess their inhibitory effect on the human monoamine oxidase (hMAO) A and B isoforms. Different (un)substituted (hetero)aromatic substituents were linked to N1 of the hydrazone in order to establish robust structure-activity relationships. The results of the biological testing demonstrated that the presence of the hydrazothiazole nucleus bearing at C4 a phenyl ring functionalised at t ...[more]