Effects of vaginal conjugated equine estrogens and ospemifene on the rat vaginal wall and lower urinary tract.
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ABSTRACT:
SUBMITTER: Maldonado PA
PROVIDER: S-EPMC6366548 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
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Effects of vaginal conjugated equine estrogens and ospemifene on the rat vaginal wall and lower urinary tract.
Maldonado P Antonio PA Montoya T Ignacio TI Acevedo Jesus F JF Keller Patrick W PW Word R Ann RA
Biology of reproduction 20170101 1
Although the positive effects of vaginal estrogens and the selective estrogen receptor modulator, ospemifene (OS), on the vaginal epithelium are well recognized, less is known regarding the effects of these therapies on the lower urinary tract or vaginal muscularis. Clinical evidence suggests that vaginally administered estrogen may improve overactive bladder-related symptoms. The objective of this study was to compare the effects of OS, vaginal conjugated equine estrogens (CEE), or both on the ...[more]
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