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Nitro Sulfonyl Fluorides are a new pharmacophore for the development of antibiotics.

ABSTRACT: The development of antibiotics against Gram-negative bacteria is a central problem in drug discovery. In this report, we demonstrate that aromatic sulfonyl fluorides with a nitro group in their ortho position have remarkable antibacterial activity and are active against drug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug resistant Acinetobacter baumannii, and Pseudomonas aeruginosa.

SUBMITTER: Sadlowski C

PROVIDER: S-EPMC6366622 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Nitro Sulfonyl Fluorides are a new pharmacophore for the development of antibiotics.

Sadlowski Corinne C Park Bora B Araújo Clarissa C Das Subhamoy S Kerr D Lucas DL He Maomao M Han Hesong H Riley Lee L Murthy Niren N

Molecular systems design & engineering 20180607 4

The development of antibiotics against Gram-negative bacteria is a central problem in drug discovery. In this report, we demonstrate that aromatic sulfonyl fluorides with a nitro group in their ortho position have remarkable antibacterial activity and are active against drug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug resistant Acinetobacter baumannii, and Pseudomonas aeruginosa. ...[more]

PMID: 30740245

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