Ontology highlight
ABSTRACT:
SUBMITTER: Wood HN
PROVIDER: S-EPMC6366778 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Wood Hillary N HN Venken Tom T Willems Hanny H Jacobs An A Reis Ana Júlia AJ Almeida da Silva Pedro Eduardo PE Homolka Susanne S Niemann Stefan S Rohde Kyle H KH Hooyberghs Jef J
PloS one 20190207 2
In Mycobacterium tuberculosis (Mtb) the detection of single nucleotide polymorphisms (SNPs) is of high importance both for diagnostics, since drug resistance is primarily caused by the acquisition of SNPs in multiple drug targets, and for epidemiological studies in which strain typing is performed by SNP identification. To provide the necessary coverage of clinically relevant resistance profiles and strain types, nucleic acid-based measurement techniques must be able to detect a large number of ...[more]