Contribution of MSMB promoter region gene polymorphism to early-onset prostate cancer risk in Mexican males.

ABSTRACT: Sexually transmitted infections and its contribution to prostate cancer (PC) development have been relevant in different populations. MSMB gene polymorphism (rs10993994) has exhibited an association both with PC as well as the susceptibility to sexually transmitted infections. Hitherto, these conditions have been not studied in Mexico yet, neither if sexually transmitted infections could modify the MSMB and PC association. Herein, socio-demographic features, sexually transmitted infections records, the reproductive backgrounds, and the genetic characterisation were analysed in 322 incident PC cases and 628 population healthy controls from Mexico City. Whole PC, early-onset PC (PC at < 60 years old), late-onset PC (≥ 60 years old), and PC aggressiveness were used to evaluate the gene

SUBMITTER: Trujillo-Caceres SJ 

PROVIDER: S-EPMC6366823 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature