Ontology highlight
ABSTRACT:
SUBMITTER: Laursen MB
PROVIDER: S-EPMC6366826 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Laursen Maria Bach MB Reinholdt Linn L Schönherz Anna Amanda AA Due Hanne H Jespersen Ditte Starberg DS Grubach Lykke L Ettrup Marianne Schmidt MS Røge Rasmus R Falgreen Steffen S Sørensen Suzette S Bødker Julie Støve JS Schmitz Alexander A Johnsen Hans E HE Bøgsted Martin M Dybkær Karen K
Oncotarget 20190122 7
Survival of diffuse large B-cell lymphoma (DLBCL) patients has improved by inclusion of rituximab. Refractory/recurrent disease caused by treatment resistance is, however, a major problem. Determinants of rituximab sensitivity are not fully understood, but effect of rituximab are enhanced by antagonizing cell surface receptor CXCR4. In a two-step strategy, we tested the hypothesis that prognostic value of CXCR4 in DLBCL relates to rituximab treatment, due to a hampering effect of CXCR4 on the re ...[more]