Ontology highlight
ABSTRACT:
SUBMITTER: Marchetto MC
PROVIDER: S-EPMC6366899 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
eLife 20190207
Comparative analyses of neuronal phenotypes in closely related species can shed light on neuronal changes occurring during evolution. The study of post-mortem brains of nonhuman primates (NHPs) has been limited and often does not recapitulate important species-specific developmental hallmarks. We utilize induced pluripotent stem cell (iPSC) technology to investigate the development of cortical pyramidal neurons following migration and maturation of cells grafted in the developing mouse cortex. O ...[more]