Ontology highlight
ABSTRACT:
SUBMITTER: Batra J
PROVIDER: S-EPMC6366944 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Batra Jyoti J Hultquist Judd F JF Liu Dandan D Shtanko Olena O Von Dollen John J Satkamp Laura L Jang Gwendolyn M GM Luthra Priya P Schwarz Toni M TM Small Gabriel I GI Arnett Eusondia E Anantpadma Manu M Reyes Ann A Leung Daisy W DW Kaake Robyn R Haas Paige P Schmidt Carson B CB Schlesinger Larry S LS LaCount Douglas J DJ Davey Robert A RA Amarasinghe Gaya K GK Basler Christopher F CF Krogan Nevan J NJ
Cell 20181201 7
Ebola virus (EBOV) infection often results in fatal illness in humans, yet little is known about how EBOV usurps host pathways during infection. To address this, we used affinity tag-purification mass spectrometry (AP-MS) to generate an EBOV-host protein-protein interaction (PPI) map. We uncovered 194 high-confidence EBOV-human PPIs, including one between the viral transcription regulator VP30 and the host ubiquitin ligase RBBP6. Domain mapping identified a 23 amino acid region within RBBP6 that ...[more]