Examination of the shared genetic basis of anorexia nervosa and obsessive-compulsive disorder.

ABSTRACT: Anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) are often comorbid and likely to share genetic risk factors. Hence, we examine their shared genetic background using a cross-disorder GWAS meta-analysis of 3495 AN cases, 2688 OCD cases, and 18,013 controls. We confirmed a high genetic correlation between AN and OCD (r_g = 0.49 ± 0.13, p = 9.07 × 10^-7) and a sizable SNP heritability (SNP h² = 0.21 ± 0.02) for the cross-disorder phenotype. Although no individual loci reached genome-wide significance, the cross-disorder phenotype showed strong positive genetic correlations with other psychiatric phenotypes (e.g., r_g = 0.36 with bipolar disorder and 0.34 with neuroticism) and negative genetic correlations with metabolic phenotypes (e.g., r

SUBMITTER: Yilmaz Z 

PROVIDER: S-EPMC6367065 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature