Ontology highlight
ABSTRACT:
SUBMITTER: Majewski DD
PROVIDER: S-EPMC6367419 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Majewski Dorothy D DD Worrall Liam J LJ Hong Chuan C Atkinson Claire E CE Vuckovic Marija M Watanabe Nobuhiko N Yu Zhiheng Z Strynadka Natalie C J NCJ
Nature communications 20190207 1
Many Gram-negative bacteria, including causative agents of dysentery, plague, and typhoid fever, rely on a type III secretion system - a multi-membrane spanning syringe-like apparatus - for their pathogenicity. The cytosolic ATPase complex of this injectisome is proposed to play an important role in energizing secretion events and substrate recognition. We present the 3.3 Å resolution cryo-EM structure of the enteropathogenic Escherichia coli ATPase EscN in complex with its central stalk EscO. T ...[more]