Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC6367586 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Yang Yang Y Wang He-Xiao HX Zhang Lan L Huo Wei W Li Xiao-Dong XD Qi Rui-Qun RQ Song Xiao-Yu XY Wei Shi S Gao Xing-Hua XH Han Shuai S Cao Liu L
International journal of biological sciences 20190101 3
Hyperthermia has been clinically utilized as an adjuvant therapy in the treatment of cervical carcinoma. However, thermotolerance induced by heme oxygenase-1 (HO-1), a stress-inducible cytoprotective protein, limits the efficacy of hyperthermic therapy, for which the exact mechanism remains unknown. In the present study, we found that heat treatment induced HO-1 expression and decreased copy number of HPV16 in cervical cancer cells and tissues from cervical cancer and precursor lesions. Knockdow ...[more]