Ambient Ionization Mass Spectrometry for Point-of-Care Diagnostics and Other Clinical Measurements.

ABSTRACT:

Background

One driving motivation in the development of point-of-care (POC) diagnostics is to conveniently and immediately provide information upon which healthcare decisions can be based, while the patient is on site. Ambient ionization mass spectrometry (MS) allows direct chemical analysis of unmodified and complex biological samples. This suite of ionization techniques was introduced a decade ago and now includes a number of techniques, all seeking to minimize or eliminate sample preparation. Such approaches provide new opportunities for POC diagnostics and rapid measurements of exogenous and endogenous molecules (e.g., drugs, proteins, hormones) in small volumes of biological samples, especially when coupled with miniature mass spectrometers.

Content

Ambient MS-based tec

SUBMITTER: Ferreira CR 

PROVIDER: S-EPMC6367930 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature