Ontology highlight
ABSTRACT:
SUBMITTER: Achuthan V
PROVIDER: S-EPMC6368089 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Achuthan Vasudevan V Perreira Jill M JM Sowd Gregory A GA Puray-Chavez Maritza M McDougall William M WM Paulucci-Holthauzen Adriana A Wu Xiaolin X Fadel Hind J HJ Poeschla Eric M EM Multani Asha S AS Hughes Stephen H SH Sarafianos Stefan G SG Brass Abraham L AL Engelman Alan N AN
Cell host & microbe 20180830 3
HIV-1 integration into the host genome favors actively transcribed genes. Prior work indicated that the nuclear periphery provides the architectural basis for integration site selection, with viral capsid-binding host cofactor CPSF6 and viral integrase-binding cofactor LEDGF/p75 contributing to selection of individual sites. Here, by investigating the early phase of infection, we determine that HIV-1 traffics throughout the nucleus for integration. CPSF6-capsid interactions allow the virus to by ...[more]