Dataset Information

? Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.

ABSTRACT: Many patients with type 1 diabetes (T1D) have residual ? cells producing small amounts of C-peptide long after disease onset but develop an inadequate glucagon response to hypoglycemia following T1D diagnosis. The features of these residual ? cells and ? cells in the islet endocrine compartment are largely unknown, due to the difficulty of comprehensive investigation. By studying the T1D pancreas and isolated islets, we show that remnant ? cells appeared to maintain several aspects of regulated insulin secretion. However, the function of T1D ? cells was markedly reduced, and these cells had alterations in transcription factors constituting ? and ? cell identity. In the native pancreas and after placing the T1D islets into a non-autoimmune, normoglycemic in vivo environment, there was no evidence of ?-to-? cell conversion. These results suggest an explanation for the disordered T1D counterregulatory glucagon response to hypoglycemia.

SUBMITTER: Brissova M

PROVIDER: S-EPMC6368357 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.

Brissova Marcela M Haliyur Rachana R Saunders Diane D Shrestha Shristi S Dai Chunhua C Blodgett David M DM Bottino Rita R Campbell-Thompson Martha M Aramandla Radhika R Poffenberger Gregory G Lindner Jill J Pan Fong Cheng FC von Herrath Matthias G MG Greiner Dale L DL Shultz Leonard D LD Sanyoura May M Philipson Louis H LH Atkinson Mark M Harlan David M DM Levy Shawn E SE Prasad Nripesh N Stein Roland R Powers Alvin C AC

Cell reports 20180301 10

Many patients with type 1 diabetes (T1D) have residual β cells producing small amounts of C-peptide long after disease onset but develop an inadequate glucagon response to hypoglycemia following T1D diagnosis. The features of these residual β cells and α cells in the islet endocrine compartment are largely unknown, due to the difficulty of comprehensive investigation. By studying the T1D pancreas and isolated islets, we show that remnant β cells appeared to maintain several aspects of regulated ...[more]

PMID: 29514095

Dataset Information

? Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.

Publications

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.

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